2006 Film Independent Spirit Awards – Best Female Lead Winner and Nominees

Transamerica

Felicity Huffman

A preoperative transgender woman takes an unexpected journey when she learns that she fathered a son, now a teenage runaway hustling on the streets of New York.

Forty Shades of Blue

Dina Korzun

Lackawanna Blues

S. Epatha Merkerson

Room

Cyndi Williams

The Squid and the Whale

Laura Linney